A MODIFIED DELPHI APPROACH TO DEVELOP A TRIAL PROTOCOL FOR ANTIBIOTIC DE-ESCALATION IN PATIENTS WITH SUSPECTED SEPSIS

A modified Delphi approach to develop a trial protocol for antibiotic de-escalation in patients with suspected sepsis

Abstract Background: Early administration of antibiotics in sepsis is associated with improved patient outcomes, but safe and generalizable approaches to de-escalate or discontinue antibiotics after suspected sepsis events are unknown.Methods: We Test Boards used a modified Delphi approach to identify safety criteria for an opt-out protocol to guid

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Study of obesity associated proopiomelanocortin gene polymorphism: Relation to metabolic profile and eating habits in a sample of obese Egyptian children and adolescents

Background: Melanocortinergic system represents a known system involved in the central regulation of body weight with the central proopiomelanocortin (POMC) neurons forming a potent anorexigenic network.Polymorphisms in the POMC gene locus are associated with obesity phenotypes.Aim: To assess the contribution of the POMC gene 9-bp insertional polym

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